1,1'-Thiocarbonyldiimidazole → HCID 59550995, compound

HRID 511872Notes

Reaction equation

HRID 511872 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2].[C:16](N1C=CN=C1)(N1C=CN=C1)=[S:17]>ClCCl>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N:15]=[C:16]=[S:17])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 59551030HCID 59551030, compound

Product 1

HCID 59550995HCID 59550995, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-isopropyl-7-methoxy-1H-indol-4-ylamine (U) (1 eq) in dichloromethane was added 1,1′-thiocarbonyldiimidazole (1.2 eq). The reaction was stirred for 2 hrs at room temperature then evaporated to dryness. Further purification by column chromatography produced the pure desired product.

Workup

  1. customthen evaporated to dryness
  2. customFurther purification by column chromatography

Sources & evidence

ORD record
ord-c65c0c880246498d85ccb19c5e8d9a5d
Source dataset
uspto-grants-2015_08
Patent number
US09101614B2

Reaction notes

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