Boron tribromide → HCID 66931231, compound

HRID 511961Notes

Reaction equation

HRID 511961 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]OC2C=CC=CC=2)[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)[Br:24]>C(Cl)Cl>[Br:24][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([OH:2])[CH:4]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 66931303HCID 66931303, compound

Product 1

HCID 66931231HCID 66931231, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

7-Bromo-1-(3-hydroxy-phenyl)-heptane (9.2) was synthesized as in 9.1 using 8.2 (0.50 g, 1.68 mmol), in anhydrous CH2Cl2 (16 mL), and BBr3 (1M solution in CH2Cl2, 3.7 mL, 3.7 mmol). The title compound (9.2) was isolated as a viscous liquid after purification by flash column chromatography (0.420 g, 92% yield).

Sources & evidence

ORD record
ord-89944dad47fe49f18e5b4afff1910270
Source dataset
uspto-grants-2015_08
Patent number
US09102622B2

Reaction notes

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