Boron trifluoride etherate → HCID 25017607, compound

HRID 511979Notes

Reaction equation

HRID 511979 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][S:22]([F:25])(=[O:24])=[O:23])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.B(F)(F)F.CCOCC>C(S)(S)C>[OH:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][S:22]([F:25])(=[O:24])=[O:23])[CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 8000Boron trifluoride etherateHCID 25017345HCID 25017345, compound

Product 1

HCID 25017607HCID 25017607, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 336451,1-EthanedithiolSolvent

Procedure

7-(3-Hydroxy-phenyl)-heptanesulfonyl fluoride (14.2) was synthesized as described in 14.1 using 13.2 (0.1 g, 0.26 mmol) in ethanedithiol (5 mL) and BF3.Et2O (0.14 g, 1.0 mmol). Purification by flash column chromatography on silica gel gave 14.2 (0.049 g, 69% yield) as a viscous liquid.

Workup

  1. custom7-(3-Hydroxy-phenyl)-heptanesulfonyl fluoride (14.2) was synthesized
  2. customPurification by flash column chromatography on silica gel

Sources & evidence

ORD record
ord-38afe942411f4d9fa82c83d1d14296b8
Source dataset
uspto-grants-2015_08
Patent number
US09102622B2

Reaction notes

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