反应详情

The title compound was synthesized analogously to 73.2 (see experimental below), using 72 (190 mg, 1 mmol), n-BuLi (2.5 M solution in hexane, 0.4 mL, 1 mmol), MgBr2.Et2O (284 mg, 1.1 mmol) and 68.1 (132 mg, 0.5 mmol). The crude obtained after workup was chromatographed over a column of silica gel, eluting with 30% ethyl acetate-petroleum ether to give 73.1 as a white solid (m p 61-63° C.) in 53% yield (104 mg).

1. customThe title compound was synthesized analogously to 73.2 (see experimental below)
2. customThe crude obtained after workup
3. customwas chromatographed over a column of silica gel
4. washeluting with 30% ethyl acetate-petroleum ether