Lithium Hydroxide → 4-{[(5-Chloro-6-isobutoxypyridin-3-yl)oxy]methyl}-2,5-difluorobenzoic acid

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Reaction Steps

To a solution of methyl 4-((5-chloro-6-isobutoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate (Preparation 4, 623 mg, 1.6 mmol) in THF (10 mL) was added lithium hydroxide (1.8 mL of a 1 M solution in water) and the mixture stirred at room temperature under nitrogen for 18 hours. The solvent was evaporated in vacuo to give the title compound (352 mg, 59%) as a pale yellow solid and was used directly in the next step.

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