Hydrochloric Acid → 4-((5-Chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoic acid

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Reaction Steps

A solution of ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate (Preparation 32, 112 mg, 0.313 mmol) in THF (3 mL) was treated with aqueous lithium hydroxide (1 M, 1.6 mL, 1.60 mmol) and stirred at room temperature. After 2% hours the reaction mixture was acidified with aqueous hydrochloric acid solution (2 N, 15 mL) and extracted with EtOAc (2×25 mL). The combined organic extracts were dried over magnesium sulfate and evaporated to afford the title compound as a white solid (100 mg, 97%).

Provenance & Evidence