Lithium Hydroxide → HCID 66667776, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of in 4-((5-chloro-6-isobutoxypyridin-3-yloxy)methyl)-3-methoxybenzoate (Preparation 34, 405 mg, 1.07 mmol) in methanol (30.0 mL) was added aqueous lithium hydroxide (1 M, 1.17 mmol, 1.17 mL) and heated at 60° C. for 16 hours. Aqueous lithium hydroxide (1 M, 0.212 mmol, 0.212 mL) was then added and the reaction mixture was heated at 60° C. for 5.5 hours. The reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure to yield the title compound as pale yellow solid:

Provenance & Evidence