Isoamyl Nitrite → HCID 86682571, compound

Participants

Reaction Conditions

Reaction Steps

An aqueous solution of tetrafluoroboric acid (48% weight, 1.86 mL, 14.2 mmol) was added to a solution of 5-chloro-6-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)pyridin-3-amine (Preparation 52, 2.0 g, 6.79 mmol) in ethanol (3 mL) at −5° C. Isopentyl nitrite (960 μL, 7.0 mmol) was added dropwise and the reaction mixture was stirred for 30 minutes at −5° C. The suspension was filtered and the solid was washed with cold ethanol and diethyl ether to afford the title compound as a pink solid (728 mg, 27%).

Provenance & Evidence