Potassium Iodide → HCID 86682573, compound

Participants

Reaction Steps

Potassium iodide (421 mg, 2.53 mmol) was added to a solution of 5-chloro-6-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)pyridine-3-diazonium tetra fluoroborate (Preparation 53, 200 mg, 0.51 mmol) in acetone (10 mL). The mixture was stirred for 15 minutes at room temperature then concentrated in vacuo. The resulting crude residue was partitioned between EtOAc and water. The aqueous layer was further extracted with EtOAc. The combined organics were dried over magnesium sulfate and concentrated in vacuo. The crude material was purified by silica gel chromatography eluting with 10% diethyl ether in heptane to afford the title compound as an orange oil.

Provenance & Evidence