HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,5-difluoro-4-hydroxy-N-(methylsulfonyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-tert-butoxy-2,5-difluoro-N-(methylsulfonyl)benzamide | HCID 58042391 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,5-difluoro-4-hydroxy-N-(methylsulfonyl)benzamide | HCID 58042416 | 103.5% |
Reaction Steps
Hydrochloric acid solution in dioxane (4 M, 30 mL) was added to the 4-tert-butoxy-2,5-difluoro-N-(methylsulfonyl)benzamide (Preparation 109, 1.76 g, 5.73 mmol) and the resulting solution stirred at room temperature. After 3 hours the reaction mixture was concentrated in vacuo and the residue azeotroped repeatedly with DCM to yield the title compound as a white solid (1.49 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102621B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d964ac9ce6614598bd640008a2be1ee3 |
| Source note | uspto-grants-2015_08 |