HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-Hydroxyimino-5-methyl-5-phenyl-3-phenylamino-thiazolidine-2-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 4-Imino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione | HCID 11392847 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Hydroxyimino-5-methyl-5-phenyl-3-phenylamino-thiazolidine-2-thione | HCID 86588495 | 52.2% |
Reaction Steps
A solution of 4-imino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione (0.31 g) and hydroxylamine hydrochloride (0.16 g) in methanol (15 ml) was refluxed for 6 hrs followed by solvent evaporation. The residue was purified by column chromatography (ethyl acetate-n-hexane, ⅓) to yield 4-hydroxyimino-5-methyl-5-phenyl-3-phenylamino-thiazolidine-2-thione (0.17 g) having a melting point of 83-84° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713629B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-851c37619dad4ea9a4ed29136ef3dd60 |
| Source note | uspto-grants-2004_03 |