HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azane;hydrate → 2-(Pyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azane;hydrate | HCID 12896473 | — |
| Reactant | 2-(Pyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile | HCID 86716203 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Pyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)ethanamine | HCID 86716204 | 82.5% |
Reaction Steps
A mixture of 2-(pyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile (360 mg, 1.36 mmol) and NH3.H2O (2 mL) in MeOH (30 mL) was hydrogenated with Raney Ni (700 mg) under H2 (50 Psi) for 5 h. The reaction mixture was filtered and concentrated to give 2-(pyridin-4-yl)-2-(6-(trifluoromethyl)pyridin-3-yl)ethanamine (300 mg), which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8afa8800b84a4ec183973c836b918eae |
| Source note | uspto-grants-2015_08 |