反应详情

2-Isopropoxy-2-(2-methylpyrimidin-5-yl)acetonitrile (169 mg, 0.884 mmol) was dissolved in methanol (10 ml) and 7M NH3 in methanol (4 ml). Argon was bubbled through the solution for 5 minutes. To the reaction was added Raney nickel (100 mg, 1.704 mmol) and it was fitted with a H2-filled balloon. After stirring at room temperature for 20 hours LCMS shows only around 30% conversion and raney nickel (100 mg, 1.70 mmol) was added. The reaction was stirred for another 72 hours, then filtered through a plug of celite and concentrated in vacuo. The crude product used for next reaction without further purification.

1. customArgon was bubbled through the solution for 5 minutes
2. customwas fitted with a H2-
3. additionfilled balloon
4. additionwas added
5. stirringThe reaction was stirred for another 72 hours
6. filtrationfiltered through a plug of celite and
7. concentrationconcentrated in vacuo
8. customThe crude product used for next reaction without further purification