HCID 86716231, compound → HCID 86716230, compound

HRID 512203Notes

Reaction equation

HRID 512203 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([CH:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[CH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3]1>CO>[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]([CH:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:4]=[N:3]1

Participants

3

Reactant 1

HCID 86716231HCID 86716231, compound

Product 1

HCID 86716230HCID 86716230, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 3-(1-methyl-1H-pyrazol-4-yl)-3-(tetrahydro-2H-pyran-4-yl)acrylate (205 mg, 0.78 mmol) was dissolved in methanol (10 ml) and argon was bubbled through the solution for 5 minutes. To the solution was added 10% Pd/C (41 mg) and the flask was fitted with a balloon containing hydrogen. The reaction was stirred at room temperature for 16 hours. The catalyst was removed by filtration through a plug of celite. And solution was concentrated in vacuo. The crude product was used directly in the next reaction.

Workup

  1. customargon was bubbled through the solution for 5 minutes
  2. additionTo the solution was added 10% Pd/C (41 mg)
  3. customthe flask was fitted with a balloon
  4. additioncontaining hydrogen
  5. customThe catalyst was removed by filtration through a plug of celite
  6. concentrationAnd solution was concentrated in vacuo
  7. customThe crude product was used directly in the next reaction

Sources & evidence

ORD record
ord-e2d1e525a92f4bdd9251c669884ed1e0
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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