2-Chloro-5-methylbenzoic Acid → 2-Chloro-5-methyl-N-(1-pyridin-3-yl-cyclopentylmethyl)-benzamide

HRID 512214Notes

Reaction equation

HRID 512214 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]2([CH2:23][NH2:24])[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:13]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([NH:24][CH2:23][C:18]1([C:14]2[CH:13]=[N:12][CH:17]=[CH:16][CH:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:6]

Participants

3

Reactant 2

HCID 2404302-Chloro-5-methylbenzoic AcidHCID 55265176[1-(Pyridin-3-yl)cyclopentyl]methanamine

Product 1

HCID 867162472-Chloro-5-methyl-N-(1-pyridin-3-yl-cyclopentylmethyl)-benzamide

Procedure

From 2-chloro-5-methylbenzoic acid and C-(1-pyridin-3-yl-cyclopentyl)-methylamine. LCMS (MH+): m/z=329.0, tR (minutes, Method A)=1.14

Sources & evidence

ORD record
ord-8ead2249ba754552aa6d3c41fc5a0139
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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