2,3-Dimethylbenzoic acid → 2,3-Dimethyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

HRID 512217Notes

Reaction equation

HRID 512217 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][N:13]1[CH2:18][CH2:17][C:16]([CH2:25][NH2:26])([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:14]1>>[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:26][CH2:25][C:16]1([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:15][CH2:14][N:13]([CH3:12])[CH2:18][CH2:17]1)=[O:6]

Participants

3

Reactant 2

HCID 117822,3-Dimethylbenzoic acidHCID 343885(1-Methyl-4-phenylpiperidin-4-yl)methanamine

Product 1

HCID 867162502,3-Dimethyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

Procedure

From 2,3-dimethylbenzoic acid and C-(1-methyl-4-phenyl-piperidin-4-yl)-methylamine. LCMS (MH30 ) m/z=337.0, tR (minutes, Method A)=0.65

Sources & evidence

ORD record
ord-4f03d3ff4a5c4736ab3d2f11702fe533
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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