2-Methylbenzoic acid → 2-Methyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

HRID 512219Notes

Reaction equation

HRID 512219 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][N:12]1[CH2:17][CH2:16][C:15]([CH2:24][NH2:25])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:14][CH2:13]1>>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:25][CH2:24][C:15]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:14][CH2:13][N:12]([CH3:11])[CH2:17][CH2:16]1)=[O:6]

Participants

3

Reactant 2

HCID 83732-Methylbenzoic acidHCID 343885(1-Methyl-4-phenylpiperidin-4-yl)methanamine

Product 1

HCID 867162522-Methyl-N-(1-methyl-4-phenyl-piperidin-4-ylmethyl)-benzamide

Procedure

From 2-methylbenzoic acid and C-(1-methyl-4-phenyl-piperidin-4-yl)-methylamine. LCMS (MH+): m/z=323.1, tR (minutes, Method A)=0.56

Sources & evidence

ORD record
ord-10ef5e8622ed4394a833d5b2d8f90073
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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