2-Methylbenzoic acid → 2-Methyl-N-[4-(6-methyl-pyridin-3-yl)-tetrahydro-pyran-4-ylmethyl]-benzamide
Reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][C:12]1[N:17]=[CH:16][C:15]([C:18]2([CH2:24][NH2:25])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:25][CH2:24][C:18]1([C:15]2[CH:16]=[N:17][C:12]([CH3:11])=[CH:13][CH:14]=2)[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1)=[O:6]Participants
3
Procedure
From 2-methylbenzoic acid and C-[4-(6-methylpyridin-3-yl)-tetrahydropyran-4-yl]methylamine. LCMS (MH+): m/z=325.0, tR (minutes, Method B)=0.60
Sources & evidence
- ORD record
- ord-c27840fdca8c48039d9014be58753636
- Source dataset
- uspto-grants-2015_08
- Patent number
- US09102591B2
Reaction notes
Loading…