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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512229Generated: October 25, 2026

2-Chloro-5-(trifluoromethyl)benzoic acid → 2-Chloro-N-[[4,4-difluoro-1-(6-fluoro-3-pyridyl)cyclohexyl]methyl]-5-(trifluoromethyl)benzamide

https://huagongshe.com/reaction/512229

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-(trifluoromethyl)benzoic acidHCID 688182—
Reactant[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamineHCID 86716261—
Product2-Chloro-N-[[4,4-difluoro-1-(6-fluoro-3-pyridyl)cyclohexyl]methyl]-5-(trifluoromethyl)benzamideHCID 86716264—

Reaction Steps

From 2-chloro-5-trifluoromethylbenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=451.1, tR (minutes, Method C)=1.15

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-25e494ed761c4756b2ff1653407bedc4
Source noteuspto-grants-2015_08