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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512230Generated: October 31, 2026

4-Cyano-2-fluorobenzoic acid → 4-Cyano-N-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-benzamide

https://huagongshe.com/reaction/512230

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Cyano-2-fluorobenzoic acidHCID 590659—
Reactant[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamineHCID 86716261—
Product4-Cyano-N-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-benzamideHCID 86716265—

Reaction Steps

From 2-fluoro-4-cyanobenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=392.1, tR (minutes, Method D)=0.68

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-27f861b7b00f4c42b560ba838bec922a
Source noteuspto-grants-2015_08