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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512233Generated: October 29, 2026

2-Fluoro-3-methylbenzoic acid → N-[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-3-methyl-benzamide

https://huagongshe.com/reaction/512233

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Fluoro-3-methylbenzoic acidHCID 2737379—
Reactant[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamineHCID 86716261—
ProductN-[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexylmethyl]-2-fluoro-3-methyl-benzamideHCID 86716268—

Reaction Steps

From 2-fluoro-3-methylbenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=381.1, tR (minutes, Method D)=0.74

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-e690af37f3f94d068bdc39f2f1df73d9
Source noteuspto-grants-2015_08