2-Chloro-5-methoxybenzoic acid → HCID 86716271, compound

HRID 512236Notes

Reaction equation

HRID 512236 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:13][C:14]1([F:29])[CH2:19][CH2:18][C:17]([CH2:27][NH2:28])([C:20]2[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=2)[CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([NH:28][CH2:27][C:17]1([C:20]2[CH:21]=[N:22][C:23]([F:26])=[CH:24][CH:25]=2)[CH2:18][CH2:19][C:14]([F:13])([F:29])[CH2:15][CH2:16]1)=[O:6]

Participants

3

Reactant 2

HCID 2215032-Chloro-5-methoxybenzoic acidHCID 86716261[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine

Product 1

HCID 86716271HCID 86716271, compound

Procedure

From 2-chloro-5-methoxybenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=413.1, tR (minutes, Method D)=0.72

Sources & evidence

ORD record
ord-7fadd113e5074acda6eb9073e8624849
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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