2,3-Difluorobenzoic acid → HCID 86716272, compound

HRID 512237Notes

Reaction equation

HRID 512237 reaction equation
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]1([F:28])[CH2:18][CH2:17][C:16]([CH2:26][NH2:27])([C:19]2[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=2)[CH2:15][CH2:14]1>>[F:28][C:13]1([F:12])[CH2:14][CH2:15][C:16]([CH2:26][NH:27][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:2]=2[F:1])([C:19]2[CH:20]=[N:21][C:22]([F:25])=[CH:23][CH:24]=2)[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 3705902,3-Difluorobenzoic acidHCID 86716261[4,4-Difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine

Product 1

HCID 86716272HCID 86716272, compound

Procedure

From 2,3-difluorobenzoic acid and C-[4,4-difluoro-1-(6-fluoro-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=385.0, tR (minutes, Method D)=0.71

Sources & evidence

ORD record
ord-e7af576adaae4d98bb1587e48abf4672
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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