2-Methylbenzoic acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-benzamide

HRID 512242Notes

Reaction equation

HRID 512242 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:11][C:12]1([F:30])[CH2:17][CH2:16][C:15]([CH2:28][NH2:29])([C:18]2[CH:19]=[N:20][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:22][CH:23]=2)[CH2:14][CH2:13]1>>[F:30][C:12]1([F:11])[CH2:13][CH2:14][C:15]([CH2:28][NH:29][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=2[CH3:1])([C:18]2[CH:19]=[N:20][C:21]([C:24]([F:25])([F:26])[F:27])=[CH:22][CH:23]=2)[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 83732-Methylbenzoic acidHCID 86716274(4,4-Difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methanamine

Product 1

HCID 86716280N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-2-methyl-benzamide

Procedure

From 2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=413.2, tR (minutes, Method D)=0.74

Sources & evidence

ORD record
ord-cbd4f4bb0e3e4ed9b9eb9dedc1a91fe1
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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