3-Methoxy-2-MethylBenzoic Acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-3-methoxy-2-methyl-benzamide

HRID 512248Notes

Reaction equation

HRID 512248 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH3:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[F:13][C:14]1([F:32])[CH2:19][CH2:18][C:17]([CH2:30][NH2:31])([C:20]2[CH:21]=[N:22][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:25]=2)[CH2:16][CH2:15]1>>[F:32][C:14]1([F:13])[CH2:15][CH2:16][C:17]([CH2:30][NH:31][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[C:4]=2[CH3:12])([C:20]2[CH:21]=[N:22][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:24][CH:25]=2)[CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 70214833-Methoxy-2-MethylBenzoic AcidHCID 86716274(4,4-Difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methanamine

Product 1

HCID 86716287N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-3-methoxy-2-methyl-benzamide

Procedure

From 3-methoxy-2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=443.2, tR (minutes, Method D)=0.78

Sources & evidence

ORD record
ord-545f6926a05a4e9e93125c8d16a8d8e5
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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