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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512249Generated: October 26, 2026

5-Fluoro-2-methylbenzoic acid → N-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-5-fluoro-2-methyl-benzamide

https://huagongshe.com/reaction/512249

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
Reactant(4,4-Difluoro-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexyl)methanamineHCID 86716274—
ProductN-[4,4-Difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexylmethyl]-5-fluoro-2-methyl-benzamideHCID 86716288—

Reaction Steps

From 5-fluoro-2-methylbenzoic acid and C-[4,4-difluoro-1-(6-trifluoromethyl-pyridin-3-yl)-cyclohexyl]-methylamine. LCMS (MH+): m/z=431.2, tR (minutes, Method D)=0.79

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-7e3cdc27b29c472f8b3319947c06ab9e
Source noteuspto-grants-2015_08