2,3-Dichlorobenzoic acid → 2,3-Dichloro-N-[3-cyclopropyl-2-[2-(trifluoromethyl)pyrimidin-5-yl]propyl]benzamide

HRID 512270Notes

Reaction equation

HRID 512270 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]([F:28])([F:27])[C:14]1[N:19]=[CH:18][C:17]([CH:20]([CH2:23][CH:24]2[CH2:26][CH2:25]2)[CH2:21][NH2:22])=[CH:16][N:15]=1>>[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:22][CH2:21][CH:20]([C:17]1[CH:16]=[N:15][C:14]([C:13]([F:28])([F:27])[F:12])=[N:19][CH:18]=1)[CH2:23][CH:24]1[CH2:26][CH2:25]1)=[O:6]

Participants

3

Reactant 2

HCID 57652,3-Dichlorobenzoic acidHCID 867163152-(2-Trifluoromethyl-pyrimidin-5-yl)-3-cyclopropyl-propylamine

Product 1

HCID 867163142,3-Dichloro-N-[3-cyclopropyl-2-[2-(trifluoromethyl)pyrimidin-5-yl]propyl]benzamide

Procedure

From 2,3-dichlorobenzoic acid and 2-(2-trifluoromethyl-pyrimidin-5-yl)-3-cyclopropyl-propylamine. LCMS (MH+): m/z=418.1, tR (minutes, Method G)=2.55

Sources & evidence

ORD record
ord-ccef48bbc136488fbe2d1bf3e11e4ea0
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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