2-Chloro-5-(methylsulphonyl)benzoic acid → 2-chloro-N-(3-cyclopropyl-2-(6-(trifluoromethyl)pyridin-3-yl)propyl)-5-(methyl sulfonyl)benzamide

HRID 512275Notes

Reaction equation

HRID 512275 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH:15]1([CH2:18][CH:19]([C:22]2[CH:23]=[N:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=2)[CH2:20][NH2:21])[CH2:17][CH2:16]1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([NH:21][CH2:20][CH:19]([C:22]1[CH:23]=[N:24][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:26][CH:27]=1)[CH2:18][CH:15]1[CH2:16][CH2:17]1)=[O:6]

Participants

3

Reactant 2

HCID 23291322-Chloro-5-(methylsulphonyl)benzoic acidHCID 867162843-Cyclopropyl-2-(6-trifluoromethyl-pyridin-3-yl)-propylamine

Product 1

HCID 736731862-chloro-N-(3-cyclopropyl-2-(6-(trifluoromethyl)pyridin-3-yl)propyl)-5-(methyl sulfonyl)benzamide

Procedure

From 2-chloro-5-(methylsulfonyl)benzoic acid and 3-cyclopropyl-2-(6-(trifluoromethyl)pyridin-3-yl)propan-1-amine. LCMS (MH+): m/z=461.1, tR (minutes, Method G)=2.88

Sources & evidence

ORD record
ord-35b183ce42074f988fce1e10cb79799d
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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