2-Chloro-3-fluorobenzoic acid → 2-chloro-3-fluoro-N-((4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamide

HRID 512288Notes

Reaction equation

HRID 512288 reaction equation
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:18]=[CH:17][C:16]([C:19]2([CH2:25][NH2:26])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:15][N:14]=1>>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:26][CH2:25][C:19]1([C:16]2[CH:17]=[N:18][C:13]([CH3:12])=[N:14][CH:15]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:6]

Participants

3

Reactant 2

HCID 3026202-Chloro-3-fluorobenzoic acidHCID 86716331(4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamine

Product 1

HCID 867163342-chloro-3-fluoro-N-((4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamide

Procedure

From 2-chloro-3-fluorobenzoic acid and (4-(2-methylpyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamine. LCMS (MH+): m/z=364.1, tR (minutes, Method F)=1.95

Sources & evidence

ORD record
ord-e08f8d6802b54069a5ced35a935d04b6
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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