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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512291Generated: October 30, 2026

2-Chloro-6-fluorobenzoic acid → 2-chloro-6-fluoro-N-((4-(2-(trifluoromethyl)pyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamide

https://huagongshe.com/reaction/512291

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-fluorobenzoic acidHCID 67947—
Reactant(4-(2-(trifluoromethyl)pyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamineHCID 86716336—
Product2-chloro-6-fluoro-N-((4-(2-(trifluoromethyl)pyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methyl)benzamideHCID 86716338—

Reaction Steps

From 2-chloro-6-fluorobenzoic acid and (4-(2-(trifluoromethyl)pyrimidin-5-yl)tetrahydro-2H-pyran-4-yl)methanamine. LCMS (MH+): m/z=418.1, tR (minutes, Method F)=2.17

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-232e9940e1b6468f82a01a62dc52ec50
Source noteuspto-grants-2015_08