HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl 3-(4-methyl-3-pyrrolecarboxamido)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Methyl-1H-pyrrole-3-carboxylic acid | HCID 274408 | — |
| Reactant | beta-Alanine, ethyl ester, hydrochloride | HCID 458475 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-(4-methyl-3-pyrrolecarboxamido)propionate | HCID 12146427 | 43.1% |
Reaction Steps
Using 7.63 g (60 mmol) of 4-methyl-3-pyrrolecarboxylic acid, 15.4 g (100 mmol) of β-alanine ethyl ester hydrochloride, 14 ml (100 mmol) of triethylamine, 17.3 g (90 mmol) of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 100 ml of methylene chloride, 5.80 g of the title compound were obtained in a similar manner as in Example 2 (yield: 26%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713634B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-dce44ebee5b44e60a064c654d01eafc2 |
| Source note | uspto-grants-2004_03 |