2-Chloro-3-fluorobenzoic acid → HCID 86716440, compound

HRID 512383Notes

Reaction equation

HRID 512383 reaction equation
[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]1([F:31])[CH2:18][CH2:17][C:16]([CH2:29][NH2:30])([C:19]2[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][CH:24]=2)[CH2:15][CH2:14]1>>[Cl:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:30][CH2:29][C:16]1([C:19]2[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[N:23][CH:24]=2)[CH2:17][CH2:18][C:13]([F:12])([F:31])[CH2:14][CH2:15]1)=[O:6]

Participants

3

Reactant 2

HCID 3026202-Chloro-3-fluorobenzoic acidHCID 86716351(4,4-Difluoro-1-(2-(trifluoromethyl)pyrimidin-5-yl)cyclohexyl)methanamine

Product 1

HCID 86716440HCID 86716440, compound

Procedure

From 2-chloro-3-fluorobenzoic acid and [4,4-Difluoro-1-(2-(trifluoromethyl)pyrimidin-5-yl)cyclohexyl]methanamine. LCMS (MH+): m/z=452.1, tR (minutes, Method F)=3.08

Sources & evidence

ORD record
ord-0ea3f1ccf1e64f03ac139c90a854b981
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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