Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 512384Generated: October 25, 2026

2-Chloro-3-(trifluoromethyl)benzoic acid → 2-Chloro-N-((4,4-difluoro-1-(2-(trifluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-(trifluoromethyl)benzamide

https://huagongshe.com/reaction/512384

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-3-(trifluoromethyl)benzoic acidHCID 2736677—
ReactantHCID 86716351HCID 86716351—
Product2-Chloro-N-((4,4-difluoro-1-(2-(trifluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)-3-(trifluoromethyl)benzamideHCID 86716441—

Reaction Steps

From 2-chloro-3-trifluoromethylbenzoic acid and [4,4-Difluoro-1-(2-(trifluoromethyl)pyrimidin-5-yl)cyclohexyl]methanamine. LCMS (MH+): m/z=502.1, tR (minutes, Method F)=3.25

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102591B2
Source datasetuspto-grants-2015_08
ORD IDord-b3248e2e105b4cf28de40cf65e043d74
Source noteuspto-grants-2015_08