2,3-Dichlorobenzoic acid → 2,3-dichloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)benzamide

HRID 512387Notes

Reaction equation

HRID 512387 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][CH:13]([F:30])[C:14]1[N:19]=[CH:18][C:17]([C:20]2([CH2:28][NH2:29])[CH2:25][CH2:24][C:23]([F:27])([F:26])[CH2:22][CH2:21]2)=[CH:16][N:15]=1>>[Cl:1][C:2]1[C:10]([Cl:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:29][CH2:28][C:20]1([C:17]2[CH:16]=[N:15][C:14]([CH:13]([F:30])[F:12])=[N:19][CH:18]=2)[CH2:25][CH2:24][C:23]([F:26])([F:27])[CH2:22][CH2:21]1)=[O:6]

Participants

3

Reactant 2

HCID 57652,3-Dichlorobenzoic acidHCID 86716443(1-(2-(Difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine

Product 1

HCID 867164452,3-dichloro-N-((4,4-difluoro-1-(2-(difluoromethyl)pyrimidin-5-yl)cyclohexyl)methyl)benzamide

Procedure

From 2,3-dichlorobenzoic acid and (1-(2-(difluoromethyl)pyrimidin-5-yl)-4,4-difluorocyclohexyl)methanamine. LCMS (MH+): m/z=450.1, tR (minutes, Method F)=2.98

Sources & evidence

ORD record
ord-7d88f77ec679424daa8fed3fa2d3182a
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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