HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-(trifluoromethyl)benzoic acid → HCID 73673066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-(trifluoromethyl)benzoic acid | HCID 2736677 | — |
| Reactant | 3-Cyclopropyl-2-(6-trifluoromethyl-pyridin-3-yl)-propylamine | HCID 86716284 | — |
| Product | HCID 73673066 | HCID 73673066 | — |
Reaction Steps
The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-trifluoromethylbenzoic acid and 3-cycl opropyl-2-(6-trifluoromethyl-pyridin-3-yl)-propylamine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=451.1, tR (minutes, Method G)=3.11. [α]D20=+26.0 (c=2.0 mg/mL,CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c215bf6676e843339087530d7bc6c1f7 |
| Source note | uspto-grants-2015_08 |