HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-fluorobenzoic acid → HCID 86716320, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-fluorobenzoic acid | HCID 302620 | — |
| Reactant | 3-Cyclopropyl-2-(6-trifluoromethyl-pyridin-3-yl)-propylamine | HCID 86716284 | — |
| Product | HCID 86716320 | HCID 86716320 | — |
Reaction Steps
The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-fluorobenzoic acid and 3-cyclopropyl-2-(6-(trifluoromethyl)pyridin-3-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=401.1, tR (minutes, Method G)=2.61. [α]D20=+28.13 (c=1.6 mg/mL,CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d1a21a7ba63b4e1db71ae86dae250058 |
| Source note | uspto-grants-2015_08 |