HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-methoxybenzoic acid → 2-chloro-N-(3-cyclopropyl-2-(2-(trifluoromethyl)pyrimidin-5-yl)propyl)-3-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-methoxybenzoic acid | HCID 16218063 | — |
| Reactant | 2-(2-Trifluoromethyl-pyrimidin-5-yl)-3-cyclopropyl-propylamine | HCID 86716315 | — |
| Product | 2-chloro-N-(3-cyclopropyl-2-(2-(trifluoromethyl)pyrimidin-5-yl)propyl)-3-methoxybenzamide | HCID 86716342 | — |
Reaction Steps
The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-methoxybenzoic acid and 3-cyclopropyl-2-(2-(trifluoromethyl)pyrimidin-5-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=414.0, tR (minutes, Method F)=2.53. [α]D20=+26.3 (c=4.0 mg/mL,CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102591B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8b9e2e95236a44aa9d1701b0e3a6cfe9 |
| Source note | uspto-grants-2015_08 |