反应详情

The racemic mixture which was prepared in a similar manner to example 3a from 2,3-dichlorobenzoic acid and 3-cyclopropyl-2-methyl-2-(2-(trifluoromethyl)pyrimidin-5-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=432.1, tR (minutes, Method G)=2.58. [α]D20=+17.42 (c=6.6 mg/mL,CHCl3)

1. customwas separated into the two enantiomers by preparative SFC