2-Chloro-3-fluorobenzoic acid → HCID 86716369, compound

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Reaction Steps

The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-fluorobenzoic acid and 3-(1-(trifluoromethyl)cyclopropyl)-2-(2-(trifluoromethyl)pyridin-5-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=469.1, tR (minutes, Method G)=2.54. [α]D20=+27.60 (c=3.20 mg/mL,CHCl3)

Provenance & Evidence