2-Chloro-6-fluorobenzoic acid → HCID 86716389, compound

HRID 512421Notes

Reaction equation

HRID 512421 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[F:12][C:13]1[CH:18]=[CH:17][C:16]([CH:19]([C:22]2[CH:23]=[N:24][C:25]([C:28]([F:31])([F:30])[F:29])=[N:26][CH:27]=2)[CH2:20][NH2:21])=[CH:15][CH:14]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:21][CH2:20][CH:19]([C:16]1[CH:17]=[CH:18][C:13]([F:12])=[CH:14][CH:15]=1)[C:22]1[CH:23]=[N:24][C:25]([C:28]([F:30])([F:31])[F:29])=[N:26][CH:27]=1)=[O:6]

Participants

3

Reactant 2

HCID 679472-Chloro-6-fluorobenzoic acidHCID 86716386HCID 86716386, compound

Product 1

HCID 86716389HCID 86716389, compound

Procedure

The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-6-fluorobenzoic acid and 2-(4-fluorophenyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=442.0, tR (minutes, Method F)=2.99. [α]D20=+18.1 (c=4.0 mg/mL, CHCl3)

Workup

  1. customwas separated into the two enantiomers by preparative SFC

Sources & evidence

ORD record
ord-583a26c441bc43b5b753c0067269588d
Source dataset
uspto-grants-2015_08
Patent number
US09102591B2

Reaction notes

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