2-Chloro-3-fluorobenzoic acid → HCID 86716394, compound

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Reaction Steps

The racemic mixture which was prepared in a similar manner to example 3a from 2-chloro-3-fluorobenzoic acid and 2-(4,4-difluorocyclohexyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethanamine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=466.1, tR (minutes, Method F)=2.67. [α]D20=+28.57 (c=0.56 mg/mL,CHCl3)

Provenance & Evidence