2,4-Dichlorobenzoic Acid → 2,4-dichloro-N-(3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propyl)benzamide

Participants

Reaction Steps

The racemic mixture which was prepared in a similar manner to example 3a from 2,4-dichlorobenzoic acid and 3-cyclopropyl-2-(6-(difluoromethyl)pyridin-3-yl)propan-1-amine was separated into the two enantiomers by preparative SFC to yield the title compound. LCMS (MH+): m/z=399.1, tR (minutes, Method G)=2.61. [α]D20=+29.58 (c=2.40 mg/mL,CHCl3)

Provenance & Evidence