反应详情

Next, a mixture of 2-amino-5-methoxyphenol (3c) (6.03 g, 43.33 mmol) and potassium ethyl xanthate (6.95 g, 73.33 mmol) in ethanol (80 mL) was heated at reflux for 18 h. The reaction was subsequently cooled and the solvent was removed in vacuo. The residue was taken up in ethyl acetate (150 mL), washed successively with 4N HCl, water, and brine. The organic solution was subsequently dried over Na2SO4. After filtration to remove the drying aid, the solvent was evaporated to give 6.23 g (79%) of 6-methoxybenzoxazole-2-thiol.

1. temperaturewas heated
2. temperatureat reflux for 18 h
3. temperatureThe reaction was subsequently cooled
4. customthe solvent was removed in vacuo
5. washwashed successively with 4N HCl, water, and brine
6. dry with materialThe organic solution was subsequently dried over Na2SO4
7. filtrationAfter filtration
8. customto remove the drying aid
9. customthe solvent was evaporated