反应详情

A mixture of potassium ethyl xanthate (13.4 g, 84.0 mmol) and 4-chloro-2-aminophenol (10 g, 69.6 mmol) was dissolved in absolute ethanol (200 mL). The mixture was stirred under reflux overnight. After cooling, the solvent was evaporated under reduced pressure, the residue was dissolved in water (200 mL) and treated with HOAc to adjust pH to 5. A solid formed, which was filtered and dried to afford 5-chloro-2-mercaptobenzoxazole (12.8 g, yield 99.1%).

1. temperatureunder reflux overnight
2. temperatureAfter cooling
3. customthe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in water (200 mL)
5. additiontreated with HOAc
6. customA solid formed
7. filtrationwhich was filtered
8. customdried