反应详情

温度

80 °C

Next, a mixture of potassium ethyl xanthate (4.6 g, 28.8 mmol) and crude 2-amino-5-methoxyphenol (4.0 g, 28.8 mmol) was dissolved in ethanol (150 mL). The mixture was heated at 80° C. overnight. After cooling, the solvent was evaporated under reduced pressure. The resultant residue was dissolved in water and treated with 1N HCl to pH 5, resulting in a precipitate, which was collected. The solid thus collected was purified by chromatography with petroleum ether/ethyl acetate (3:1 v/v) to afford 2-mercapto-6-methoxybenzoxazole (4.0 g, yield 77%).

1. temperatureAfter cooling
2. customthe solvent was evaporated under reduced pressure
3. dissolutionThe resultant residue was dissolved in water
4. additiontreated with 1N HCl to pH 5
5. customresulting in a precipitate, which
6. customwas collected
7. customThe solid thus collected
8. customwas purified by chromatography with petroleum ether/ethyl acetate (3:1 v/v)