Hydrochloric Acid → 5-Bromo-6-(difluoromethyl)-N-(2-methoxy-methylethyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Participants

Reaction Steps

At room temperature, 334 mg (1.19 mmol) of methyl 5-bromo-6-(difluoromethyl)-2-oxo-1,2-dihydropyridine-3-carboxylate in 3.3 ml (41 mmol) of 2-amino-1-methoxypropane were stirred for 14 h. The pH was then adjusted to 2 by addition of 1N hydrochloric acid, and the mixture was extracted with dichloromethane. Drying and concentration of the extract gave 360 mg (89% of theory) of the product.

Provenance & Evidence