HCID 86711550, compound → HCID 86711552, compound

HRID 512511Notes

Reaction equation

HRID 512511 reaction equation
[CH3:1][NH:2]C(C1C(=O)C(C2C=CN=C(C(F)(F)F)C=2)=C(C)N(C(C2C=CC(Br)=CN=2)C)C=1)=O.[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([C:50]([F:53])([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:54])[N:39]([CH:55]([C:57]2[CH:62]=[CH:61][C:60](Br)=[CH:59][N:58]=2)[CH3:56])[CH:38]=1)=[O:36])[CH3:33]>>[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([C:50]([F:53])([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:54])[N:39]([CH:55]([C:57]2[CH:62]=[CH:61][C:60]([C:1]#[N:2])=[CH:59][N:58]=2)[CH3:56])[CH:38]=1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 86711550HCID 86711550, compoundHCID 86711553HCID 86711553, compound

Product 1

HCID 86711552HCID 86711552, compound

Procedure

Example 17 is prepared as described for Example 15, substituting preparation 15b with preparation 17b. ESI mass spectrum: [M+H]+=455; Retention time HPLC: 1.03 min (Z018_S04).

Workup

  1. customExample 17 is prepared
  2. custom1.03 min (Z018_S04)

Sources & evidence

ORD record
ord-24b319ada497482794b9657d818b276b
Source dataset
uspto-grants-2015_08
Patent number
US09102624B2

Reaction notes

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