HCID 86711550, compound → HCID 86711554, compound

HRID 512512Notes

Reaction equation

HRID 512512 reaction equation
[CH3:1][NH:2]C(C1C(=O)C(C2C=CN=C(C(F)(F)F)C=2)=C(C)N(C(C2C=CC(Br)=CN=2)C)C=1)=O.[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([CH:50]([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:53])[N:39]([CH:54]([C:56]2[CH:61]=[CH:60][C:59](Br)=[CH:58][N:57]=2)[CH3:55])[CH:38]=1)=[O:36])[CH3:33]>>[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([CH:50]([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:53])[N:39]([CH:54]([C:56]2[CH:61]=[CH:60][C:59]([C:1]#[N:2])=[CH:58][N:57]=2)[CH3:55])[CH:38]=1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 86711550HCID 86711550, compoundHCID 86711555HCID 86711555, compound

Product 1

HCID 86711554HCID 86711554, compound

Procedure

Example 18 is prepared as described for Example 15, substituting preparation 15b with preparation 18b. ESI mass spectrum: [M+H]+=437; Retention time HPLC: 0.76 min (002_CA03).

Workup

  1. customExample 18 is prepared

Sources & evidence

ORD record
ord-3ad2953bdd684a52a60545b4ebbb4e2a
Source dataset
uspto-grants-2015_08
Patent number
US09102624B2

Reaction notes

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