HCID 86711550, compound → HCID 86711556, compound

HRID 512513Notes

Reaction equation

HRID 512513 reaction equation
[CH3:1][NH:2]C(C1C(=O)C(C2C=CN=C(C(F)(F)F)C=2)=C(C)N(C(C2C=CC(Br)=CN=2)C)C=1)=O.[CH2:32]([NH:34][C:35]([C:37]1[C:38](=[O:63])[C:39]([C:53]2[CH:58]=[CH:57][N:56]=[C:55]([C:59]([F:62])([F:61])[F:60])[CH:54]=2)=[C:40]([CH3:52])[N:41]([CH:43]([C:45]2[CH:50]=[CH:49][C:48](Br)=[CH:47][N:46]=2)[CH3:44])[CH:42]=1)=[O:36])[CH3:33]>>[CH2:32]([NH:34][C:35]([C:37]1[C:38](=[O:63])[C:39]([C:53]2[CH:58]=[CH:57][N:56]=[C:55]([C:59]([F:62])([F:61])[F:60])[CH:54]=2)=[C:40]([CH3:52])[N:41]([CH:43]([C:45]2[CH:50]=[CH:49][C:48]([C:1]#[N:2])=[CH:47][N:46]=2)[CH3:44])[CH:42]=1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 86711550HCID 86711550, compoundHCID 86711557HCID 86711557, compound

Product 1

HCID 86711556HCID 86711556, compound

Procedure

Example 19c is prepared as described for Example 15, substituting preparation 15b with preparation 19b. ESI mass spectrum: [M+H]+=456; Retention time HPLC: 0.96 min (Z018_S04).

Workup

  1. customExample 19c is prepared
  2. custom0.96 min (Z018_S04)

Sources & evidence

ORD record
ord-e6956032522441fa88d78f13ec4a8b4b
Source dataset
uspto-grants-2015_08
Patent number
US09102624B2

Reaction notes

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