HCID 86711550, compound → HCID 86711562, compound

HRID 512516Notes

Reaction equation

HRID 512516 reaction equation
[CH3:1][NH:2]C(C1C(=O)C(C2C=CN=C(C(F)(F)F)C=2)=C(C)N(C(C2C=CC(Br)=CN=2)C)C=1)=O.[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([C:50]([F:53])([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:54])[N:39]([CH:55]([C:58]2[CH:63]=[CH:62][C:61](Br)=[CH:60][CH:59]=2)[CH2:56][CH3:57])[CH:38]=1)=[O:36])[CH3:33]>>[CH2:32]([NH:34][C:35]([C:37]1[C:42](=[O:43])[C:41]([C:44]2[CH:49]=[CH:48][CH:47]=[C:46]([C:50]([F:53])([F:52])[F:51])[CH:45]=2)=[C:40]([CH3:54])[N:39]([CH:55]([C:58]2[CH:63]=[CH:62][C:61]([C:1]#[N:2])=[CH:60][CH:59]=2)[CH2:56][CH3:57])[CH:38]=1)=[O:36])[CH3:33]

Participants

3

Reactant 2

HCID 86711550HCID 86711550, compoundHCID 86711563HCID 86711563, compound

Product 1

HCID 86711562HCID 86711562, compound

Procedure

Example 35 is prepared as described for Example 15, substituting preparation 15b with preparation 35a. ESI mass spectrum: [M+H]+=468; Retention time HPLC: 0.51 min (Z011_S03).

Workup

  1. customExample 35 is prepared

Sources & evidence

ORD record
ord-dcdd6cddb3834860b4a016549d76a7d0
Source dataset
uspto-grants-2015_08
Patent number
US09102624B2

Reaction notes

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